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Root-Cause Evaluation · Denver · Alamosa · Telehealth

Tired All the Time? Let's Find Out Why.

Being told "your labs look normal" when you can barely get through the day isn't an answer. At Defiance Health, we run the comprehensive workup that most clinics skip — and we actually treat what we find.

"Everything came back normal."

"It's probably just stress."

"Have you tried getting more sleep?"

If you've heard these answers and your body is still telling you something's wrong, you're in the right place. Fatigue is a symptom — not a diagnosis. Finding the root cause takes comprehensive testing and a provider who's actually willing to look.

The Reality

What Chronic Fatigue Actually Looks Like

This isn't "I should probably go to bed earlier." This is your life being changed by exhaustion that doesn't respond to rest. If any of these sound familiar, it's worth investigating.

Morning exhaustion

Waking up feeling like you didn't sleep, even after 8+ hours

Afternoon crashes

Hitting a wall between 2-4 PM that coffee can't fix

Brain fog

Trouble focusing, word-finding issues, feeling "slow"

Unexplained weight changes

Gaining weight despite no change in diet, or losing it

Mood changes

Irritability, low mood, or anxiety without clear cause

Exercise intolerance

Workouts leave you wrecked for days instead of energized

Low libido

Drop in sex drive that wasn't there 6-12 months ago

Cold intolerance

Always cold, cold hands and feet, feeling "run down"

Hair loss or skin changes

Thinning hair, dry skin, brittle nails — signs of deficiency

The Root Causes

Nine Things That Could Actually Be Wrong

Chronic fatigue has real, identifiable causes. Most are missed because standard primary care visits don't include the right labs. Here's what we evaluate — and where the fix often lives.

01

Thyroid Dysfunction

An underactive thyroid is one of the most common — and most misdiagnosed — causes of fatigue. TSH alone isn't enough; you need the full panel to catch it.

Labs we check: TSH, Free T3, Free T4, Reverse T3, TPO and TgAb antibodies
Thyroid treatment →
02

Hormone Imbalance

Low testosterone in men, estrogen/progesterone dynamics in women, and perimenopause in women 35+ are enormously underdiagnosed causes of fatigue.

Labs we check: Total & free testosterone, estradiol, progesterone, SHBG, DHEA-S, FSH, LH
Hormone therapy →
03

Iron Deficiency

You can be iron-deficient with a "normal" CBC. Ferritin — your body's iron storage marker — is what actually matters, and it's rarely tested by standard primary care.

Labs we check: Ferritin, iron, TIBC, transferrin saturation, CBC
04

Vitamin D Deficiency

Especially common in Colorado winters. Low D drives fatigue, mood changes, immune dysfunction, and accelerated aging. Easy to test, easy to fix.

Labs we check: 25-hydroxy vitamin D
Vitamin D injections →
05

B12 & Methylation

B12 deficiency causes fatigue, brain fog, nerve tingling, and mood changes. MTHFR gene variants can make oral B12 poorly absorbed — that's why injectable methyl-B12 often works when pills don't.

Labs we check: B12, methylmalonic acid, homocysteine, folate
B12 injections →
06

Adrenal & Cortisol Pattern

Chronically elevated or depleted cortisol from long-term stress disrupts energy, sleep, weight, and hormones. A single morning cortisol isn't enough — the pattern across the day matters.

Labs we check: AM cortisol, 4-point salivary cortisol, DHEA-S, ACTH if indicated
07

Insulin & Blood Sugar

Early insulin resistance causes fatigue long before diabetes shows up on bloodwork. Fasting insulin is the key marker — and it's almost never tested in standard physicals.

Labs we check: Fasting glucose, fasting insulin, HOMA-IR, HbA1c, lipid panel
Metabolic support →
08

Sleep Disorders

Sleep apnea is dramatically underdiagnosed in women. Poor sleep architecture from hormone shifts, stress, or sleep-disordered breathing can cause chronic fatigue even with 8 hours in bed.

What we evaluate: Sleep history, STOP-BANG screening, referral for sleep study when indicated
09

Chronic Inflammation

Low-grade chronic inflammation from autoimmune conditions, gut issues, or lifestyle factors is a major driver of fatigue. CRP and other inflammatory markers tell the story.

Labs we check: hs-CRP, ESR, ANA, thyroid antibodies, celiac panel if indicated

Most fatigue patients have more than one cause. We don't stop at finding one — we build a complete picture so we can treat the actual drivers, not just one piece.

How We Work

From "Normal" to Actual Answers

01

Deep Intake

A real conversation about symptoms, history, timeline, and how fatigue is affecting your life.

02

Comprehensive Labs

A full panel based on your history — not the minimal default. Results typically in 5-7 days.

03

Results Review

We sit down and walk through what we found, what it means, and what we'd recommend doing about it.

04

Treatment & Follow-Up

Targeted treatment — hormones, thyroid, nutrients, peptides, lifestyle — with lab rechecks to confirm it's working.

What You Won't Hear from Us

  • "Everything looks normal."
  • "Have you tried meditation?"
  • "It's probably just stress."
  • "You just need to exercise more."
  • "Maybe you're depressed."
  • "That's just part of getting older."
  • "Your TSH is fine, so your thyroid is fine."
  • "We don't usually test for that."
Frequently Asked Questions

Fatigue Questions, Answered

Two reasons. First, standard primary care panels typically test for disease, not dysfunction — so a result can fall within the "normal" reference range while still being far from optimal for how you feel. Second, most standard panels don't include the markers that actually matter for fatigue: ferritin, free T3, reverse T3, fasting insulin, methylmalonic acid, 4-point cortisol, inflammatory markers. We run the panel that would actually answer the question.
No. Defiance Health is direct-access — you can book with us directly without a referral. Many patients continue seeing their primary care doctor for general health needs while working with us for the specialized hormone, thyroid, and fatigue workup.
Pricing depends on the depth of testing your situation calls for. A basic hormone-and-thyroid workup starts at a few hundred dollars; a comprehensive workup with expanded testing (cortisol patterns, advanced thyroid antibodies, inflammatory markers) costs more. We'll outline the expected cost during your consultation before any labs are ordered, so you can decide what makes sense. HSA/FSA cards are accepted and we provide superbills for out-of-network insurance reimbursement.
It depends on the root cause. Iron deficiency and vitamin D deficiency often produce noticeable improvement within 2-4 weeks of treatment. Thyroid replacement takes 6-8 weeks to fully dial in. Hormone optimization (TRT or BHRT) typically shows early improvements within 2-4 weeks and full effects by 3 months. Multi-factorial cases take longer because we fix one thing at a time and verify with lab rechecks.
Our workup is designed to identify serious conditions that need specialist referral — autoimmune disease, sleep apnea, undiagnosed diabetes, anemia with an underlying cause, thyroid cancer markers, and others. If we find something outside our scope, we refer you to the right specialist with your full labs and workup in hand. We're not trying to be everything to everyone — we're trying to find the answer.
Yes for patients in Colorado, Arizona, California, and Washington. We can conduct the intake, order labs at a nearby Quest or LabCorp location, review results, and manage treatment entirely virtually. Some treatment options (like IV therapy or in-office injections) require an in-person visit, but the evaluation itself can be done from anywhere in our service states.
Not necessarily. Nutrient deficiencies are correctable — once iron, B12, or vitamin D are restored and dietary sources are optimized, many patients can stop supplementing or taper. Hormone optimization is usually ongoing because the underlying decline is age-related. Thyroid replacement is typically lifelong when there's a true deficit. Your treatment plan depends on the cause, not a blanket policy.
Defiance Health is direct-pay and doesn't bill insurance. However, we provide detailed superbills that you can submit to your insurance for potential out-of-network reimbursement — many patients get partial or full reimbursement for labs and consultations. HSA and FSA cards are accepted. CareCredit and Cherry financing are available for larger treatment plans.
Fair question — it's a legitimate concern in this space. Our providers are WorldLink-certified in hormone medicine, and our practice runs on licensed medical clinicians using evidence-based treatments. We don't sell proprietary supplements, and we don't push expensive interventions you don't need. If your fatigue is from vitamin D deficiency and 4 weeks of D3 fixes it, that's the answer — no protocol to upsell. Our goal is finding the cause and treating it appropriately.
Book a consultation. The first visit is a deep intake conversation — we go through your symptoms, timeline, history, and any prior labs. At the end, we design a testing plan tailored to your situation and clearly explain the expected cost. Nothing moves forward without your decision. Book online or call (719) 480-2400.
Ready for Actual Answers?

Book a Root-Cause Evaluation

In-office at Centennial or Alamosa, or via telehealth in Colorado, Arizona, California, and Washington. A real conversation about what's going on — and a plan to find out why.

Centennial / Denver

7354 S Alton Way, Suite 102

Centennial, CO 80112

Mon–Fri · 9 AM – 5 PM

(719) 480-2400

Location details →

Alamosa · San Luis Valley

315 Edison Ave, Suite B

Alamosa, CO 81101

Mon–Fri · 9 AM – 5 PM

(719) 480-2400

Location details →

Telehealth

Colorado · Arizona · California · Washington

Full evaluation via video visit

Labs at nearby Quest or LabCorp

Ask about telehealth →