Medical Weight Loss

Compounded Semaglutide & Tirzepatide Weight Loss in Denver & Alamosa, CO

Medically supervised weight loss at Defiance Health goes far beyond "eat less, move more." We combine compounded GLP-1 medications — the same active ingredients as Ozempic, Wegovy, Mounjaro, and Zepbound — with comprehensive lab work, body composition analysis, nutrition coaching, and ongoing provider support to help you lose weight and keep it off for good.

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Up to 22%Body weight reduction (clinical trial data)
12+ yrsClinical experience
1,500+Patients served

Clinical trial averages shown above. Individual results vary based on medication, dosing, adherence, and health factors.

Compounded GLP-1 Medications

Starting at $200/mo Compounded semaglutide & tirzepatide injections
  • Compounded semaglutide
  • Compounded tirzepatide
  • Phentermine (appetite suppressant)
  • Low-dose naltrexone
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Our Approach

Comprehensive Medical Weight Loss — Not Another Fad Diet

Cleanses, crash diets, and calorie counting alone don't work for most people. Research shows that most people regain 30-35% of the weight they lose within the first year, often because the underlying causes of weight gain were never addressed.

At Defiance Health, your weight loss program is built around your complete health picture. Your provider evaluates your hormones, metabolic markers, body composition, medical history, stress levels, sleep quality, and nutrition before recommending a treatment plan.

Every patient works directly with an experienced medical provider — not a health coach or sales rep. The Defiance Health team has been successfully guiding patients through medical weight loss for over twelve years, and your treatment plan is adjusted in real time based on your labs, progress, and how you feel.

What We Evaluate

Your Custom Plan Considers

  • Hormonal balance — thyroid, testosterone, estrogen, cortisol, and insulin levels via comprehensive bloodwork
  • Body composition — lean mass vs. fat mass tracked with InBody analysis
  • Nutrition & diet — personalized meal plans and macronutrient targets
  • Physical activity — exercise guidance and optional health coaching
  • Medical history — medications, past weight loss attempts, genetic factors
  • Stress & sleep — cortisol management and sleep optimization
Getting Started

Your Weight Loss Journey in 4 Steps

From initial consultation to sustained results, every step is medically supervised and personalized to your body, goals, and lifestyle.

1

Comprehensive Evaluation

Full health assessment — bloodwork, hormone panel, body composition scan, medical history review, and honest conversation about your goals.

2

Custom Treatment Plan

Your provider builds a plan tailored to your labs and lifestyle — compounded GLP-1 medications, appetite suppressants, peptide therapy, nutrition adjustments, or a combination.

3

Active Treatment

Begin your protocol with regular check-ins (in-person or telehealth). We monitor progress through body composition scans, lab work, and weekly updates.

4

Sustain Your Results

Transition to a maintenance protocol — ongoing metabolic monitoring, nutrition support, and optional body contouring treatments.

Treatment Options

Weight Loss Medications We Prescribe

Clinically proven medications tailored to your health profile. Your provider selects the right medication — or combination — based on your labs, medical history, and goals. GLP-1 medications at Defiance Health are compounded by licensed pharmacies using the same active ingredients as their brand-name counterparts.

Compounded GLP-1

Compounded Semaglutide

The same active ingredient used in Wegovy and Ozempic, prepared by a licensed compounding pharmacy. Semaglutide mimics the GLP-1 hormone, reducing appetite and improving insulin sensitivity. Delivered as a weekly injection.

Compounded Dual GIP/GLP-1

Compounded Tirzepatide

The same active ingredient used in Mounjaro and Zepbound, prepared by a licensed compounding pharmacy. Tirzepatide targets both GLP-1 and GIP receptors for enhanced metabolic effects. Delivered as a weekly injection.

Appetite Suppressant

Phentermine

Available as Adipex or Lomaira. A well-established appetite suppressant used safely since the 1970s. Often used short-term or as part of a combination approach. Oral tablet.

Low-Dose

Low-Dose Naltrexone (LDN)

At low doses, naltrexone can modulate inflammation, improve metabolic health, and support weight loss — particularly in patients with autoimmune conditions or insulin resistance.

The Science

Why Losing Weight Is So Hard — and Why Medical Support Matters

Weight loss isn't just about willpower. Your body is biologically designed to resist it. The hypothalamus uses complex hormone interactions to maintain your current weight. When you lose weight, your body fights back by increasing hunger hormones, decreasing metabolism, and reducing unconscious movement.

Obesity is a multifactorial disease caused by genetic, hormonal, environmental, and behavioral factors. That's why exercise and diet alone fail for many people — and why medically supervised weight loss produces dramatically better outcomes.

The good news: losing even 5-10% of your body weight produces significant health improvements — lower blood pressure, improved lipids, reduced blood sugar, and decreased risk of heart disease.

5-10%Weight loss needed to significantly improve health markers
2xObese adults are twice as likely to have high blood pressure
4 lbsExtra pressure on your knees for every 2 lbs of weight gain
9-13%Increased arthritis risk for every 2 lbs of weight gain
Beyond the Scale

Post-Weight-Loss Body Contouring & Skin Tightening

Rapid weight loss can sometimes lead to loose skin. We often help patients avoid extreme changes, but when additional treatment is needed, we offer advanced non-surgical options.

EMFACE Facial Sculpting

Combines radiofrequency with HIFES to tighten facial skin, stimulate collagen, and support underlying muscle structure. Non-invasive alternative to facelift surgery.

Learn about EMFACE

Emsculpt NEO Body Contouring

Combines radiofrequency with HIFEM technology to tone skin and support muscle development. Individual results vary based on body composition and treatment adherence.

Learn about Emsculpt NEO

EXION RF Microneedling

Combines radiofrequency energy with microneedling to stimulate collagen production and tighten loose skin. Non-invasive with minimal downtime.

Learn about EXION
Why It's Worth It

Health Benefits of Medical Weight Loss

Lower Heart Disease Risk

Losing just 3-5% of body weight significantly reduces cardiovascular disease risk.

Improved Blood Pressure

Healthy weight loss directly reduces blood pressure, often decreasing or eliminating medications.

Better Blood Sugar Control

GLP-1 medications improve insulin sensitivity while you lose weight.

Reduced Joint Pain

Every pound lost removes four pounds of pressure from your knees.

More Energy & Better Sleep

Losing excess weight improves sleep quality and gives you more sustained energy.

Improved Hormone Balance

Weight loss helps normalize testosterone, estrogen, and thyroid levels.

Frequently Asked Questions

Medical Weight Loss FAQ

Results vary by individual. Clinical trials of the brand-name equivalents show average weight loss of 15 to 17 percent of body weight with semaglutide and up to 22 percent with tirzepatide over 68 to 72 weeks of treatment. Most patients see noticeable results within the first 4 to 8 weeks. Your provider monitors progress with regular body composition scans and lab work. Individual results depend on medication, dose, adherence, and overall health factors.
Most patients begin noticing reduced appetite and modest weight loss within the first 2 to 4 weeks of starting a compounded GLP-1 program. More substantial weight loss typically builds over 3 to 6 months as your dose is titrated up. Maximum clinical trial results are reached around 14 to 18 months of consistent use. We monitor closely and adjust your protocol at follow-up appointments to keep your progress on track.
Both are weekly injections prescribed at Defiance Health as compounded formulations from licensed pharmacies. Semaglutide (the same active ingredient in Wegovy and Ozempic) targets GLP-1 receptors to reduce appetite and slow gastric emptying. Tirzepatide (the same active ingredient in Mounjaro and Zepbound) targets both GLP-1 and GIP receptors for a dual mechanism that often produces greater weight loss. Your provider will recommend the best option based on your labs and goals.
Our compounded GLP-1 weight loss programs start at $200 per month and range up to $900 per month, depending on the medication, your dose, and your goals. Defiance Health is cash-pay — we accept HSA and FSA cards, offer financing through CareCredit and Cherry, and provide a superbill you can submit to your insurance for potential out-of-network reimbursement. Visit our pricing page for current rates.
Defiance Health prescribes compounded semaglutide and tirzepatide through licensed compounding pharmacies. Compounded GLP-1 medications contain the same active ingredients as brand-name Ozempic, Wegovy, Mounjaro, and Zepbound, and are often more accessible and affordable than brand options. We do not prescribe the brand-name medications directly.
Yes. Defiance Health offers full telehealth weight loss programs for residents of Colorado, Arizona, California, and Washington. Consultations happen via secure video, lab work can be completed at any Quest or Labcorp location near you, and medications are shipped directly to your door from the compounding pharmacy.
The most common side effects include nausea, decreased appetite, constipation, and occasional digestive changes — especially during the first few weeks of treatment or after a dose increase. These typically improve as your dose stabilizes. We start low and gradually titrate up to minimize side effects. Less common but more serious potential side effects will be reviewed with you during your consultation.
GLP-1 medications are not appropriate for everyone. Contraindications include a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), pregnancy or breastfeeding, and certain types of pancreatitis. Patients with a history of gallbladder disease, severe gastrointestinal conditions, or diabetic retinopathy should be evaluated carefully. Your provider will review your complete medical history and labs to determine whether GLP-1 therapy is safe and appropriate for you.
Studies show patients who stop GLP-1 medications without a maintenance plan often regain a significant portion of the weight they lost. That's why we build sustainable habits throughout treatment — nutrition coaching, exercise guidance, and metabolic monitoring. When you're ready to taper off medication, we create a specific maintenance protocol to protect your results over the long term.
Many online clinics offer a brief questionnaire followed by a prescription — with minimal clinical oversight. At Defiance Health, you work with experienced medical providers who review comprehensive bloodwork, perform body composition analysis, evaluate your hormones, and build a truly personalized plan. We also offer peptide therapy, hormone optimization, IV therapy, and body contouring — all under one roof.
Medical weight loss may be appropriate if you have a BMI of 30 or higher, or a BMI of 27 or higher with weight-related conditions like type 2 diabetes, high blood pressure, or high cholesterol. It can also be a strong option if diet and exercise haven't produced lasting results. Schedule a consultation and your provider will review your health, labs, and goals to determine if you're a candidate.
Ready to Start?

Your Weight Loss Consultation Is the First Step

Schedule a consultation with a Defiance Health provider. We'll review your health, order labs, and build a plan that fits your body and your life.

Book Your Consultation Call (719) 480-2400

Alamosa Clinic

315 Edison Ave, Suite B

Alamosa, CO 81101

(719) 480-2400

Centennial Clinic

7354 S Alton Way, Suite 102

Centennial, CO 80112

(719) 480-2400

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